In vitro reversion of amphotericin B resistance in Leishmania donovani by poloxamer 188.
نویسندگان
چکیده
A micellar formulation of amphotericin B (AmB) solubilized with poloxamer 188 was evaluated against an AmB Leishmania donovani-resistant line. A concave isobologram showed a synergistic effect of this association against promastigotes. This result was confirmed with amastigotes since the 50% effective concentration of the new formulation was 100 times less than that of the control AmB formulation.
منابع مشابه
In vitro susceptibility of field isolates of Leishmania donovani to Miltefosine and amphotericin B: correlation with sodium antimony gluconate susceptibility and implications for treatment in areas of endemicity.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 44 8 شماره
صفحات -
تاریخ انتشار 2000